Studies suggest that a functional polymorphism of the brain-derived neurotrophic factor gene (BDNFVal66Met) may contribute to methamphetamine dependence.
Our results showed that the distribution of the BDNFVal66Met genotype in Chinese subjects with methamphetamine dependence (OR=2.6, p=0.015) and methamphetamine psychosis (OR=0.2, p = 0.034) were significant compared with controls.